Uic2 antibody

Author: axcc

August undefined, 2024

WebThe UIC2 monoclonal antibody specifically binds to an extracellular epitope of CD243, which is also known as ATP-binding cassette subfamily B member 1 (ABCB1), Multidrug resistance protein 1 (MDR1), or P-glycoprotein 1. CD243 is a transmembrane glycoprotein that spans the membrane 12 times. WebThe antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze. Application FC - Quality tested. Recommended Usage Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use ...

Use of photoimmunoconjugates to characterize ABCB1 in cancer …

Web5 Oct 2024 · Human-specific MRK16 antibodies were expressed from hybridoma cells, cultured in Wheaton CeLLine Bioreactors following the producer’s recommendation, similar to the previously published UIC2 antibody method , followed by Protein G (GenScript) affinity purification and fragmentation using Fab Preparation Kit protocol (Thermo Fisher). The … WebThe mouse monoclonal antibody UIC2 recognizes an extracellular epitope on CD243 (MDR-1), an approximately 170 kDa ABC transporter expressed on hematopoietic stem cells, B, … m/ 6 facebook free friends. beatriz romas

The Strong In Vivo Anti-Tumor Effect of the UIC2 Monoclonal …

Web19 Sep 2014 · The UIC2 monoclonal antibody recognizes human Pgp and inhibits its drug transport activity. However, this inhibition is partial, since UIC2 binds only to 10-40% of … WebEach lot of this antibody is quality control tested by formalin-fixed paraffin-embedded immunohistochemical staining. For immunohistochemistry, a concentration range of 5.0 - 10 µg/ml is suggested. It is recommended that the reagent be titrated for optimal performance for each application. Web19 Sep 2014 · The UIC2 monoclonal antibody recognizes human Pgp and inhibits its drug transport activity. However, this inhibition is partial, since UIC2 binds only to 10–40% of … m6 extremity\u0027s

IM2370U, CD243-PE Conjugated Antibody, UIC2, 2 mL, ASR

Web27 Sep 2024 · UIC2 shift assay ( a) was used to evaluate the impact of verapamil, paclitaxel, and DAC-2Amide, -3Amide and -4Amide on P-gp conformation. Normalized median fluorescence intensity (MFI) upon... WebIntroduction On January 6, 2024, lecanemab (Leqembi) was granted accelerated approval by the United States Food and Drug Administration (FDA) for the treatment of early Alzheimer disease (AD). 1 The second in its class, lecanemab is preceded by the controversial amyloid beta-directed monoclonal antibody, aducanumab (Aduhelm). Like aducanumab, … kit beauty fashWebEnter the email address you signed up with and we'll email you a reset link. kit bcr/abl p210

"WebUIC2 is a monoclonal antibody that binds to the extracellular region of ABCB1, particularly extracellular loops 1, 3 and 4 [ 29 ]. Thus, it allows for labeling of cell surface-expressed ABCB1 without disrupting the plasma membrane. " - Uic2 antibody

Uic2 antibody

CD243 (ABCB1) Monoclonal Antibody (UIC2) - Thermo Fisher …

WebEach lot of this antibody is quality control tested by formalin-fixed paraffin-embedded immunohistochemical staining. For immunohistochemistry, a concentration range of 5.0 - … Web13 Feb 2024 · The ABCB1-specific inhibitory antibody UIC2 was developed with the goal of increasing antitumor drug treatment efficacy (8, 9). UIC2 targets the extracellular moiety of human ABCB1 (ABCB1 H ) and has been successfully used to investigate the transport cycle of ABCB1 owing to its ability to bind the transporter during various states of the catalytic …

Did you know?

WebApplications Tested: This UIC2 antibody has been pre-titrated and tested by flow cytometric analysis on multidrug resistant cell lines. This can be used at 5 µL (0.5 µg) per test. A test … Web27 Mar 2014 · Miele authored the 1997 Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products. In 1994, he …

WebInvitrogen Anti-P-Glycoprotein Monoclonal (UIC2), Catalog # MA5-44031. Tested in Immunohistochemistry (Frozen) (IHC (F)), Immunohistochemistry (Paraffin) (IHC (P)), … WebThe UIC2 antibody reacts with an external epitope of the human P-glycoprotein (P-gp). UIC2 antibody inhibits Pgp-mediated efflux and potentiates the cytotoxic action of P-gp transported drugs in MDR cells. Customers Also Viewed. Life Sciences Division Headquarters 5350 Lakeview Parkway S Drive

WebMouse monoclonal [UIC2] antibody to CD243 (Alexa Fluor® 647). Specificity. This antibody recognizes an extracellular epitope on CD243, an approximately 170 kDa ABC transporter … Web19 Sep 2014 · The UIC2 monoclonal antibody recognizes human Pgp and inhibits its drug transport activity. However, this inhibition is partial, since UIC2 binds only to 10–40% of …

WebClone UIC2 is a strong inhibitor of CD243-mediated efflux and of the resistance of MDR cells to CD243 transported cytotoxic drugs. Clone UIC2 can be used in a shift assay to …

WebProduct Specific Information. Description: This monoclonal antibody reacts with human Multidrug Resistant (MDR)-1, which is also known as P-glycoprotein (Pgp) and CD243. A … m6 family\u0027sWeb22 Jan 2013 · Product name PE Anti-P Glycoprotein antibody [UIC2] See all P Glycoprotein primary antibodies Description PE Mouse monoclonal [UIC2] to P Glycoprotein Host … kit beall vmwareWebFlow Cytometry - APC Anti-P Glycoprotein antibody [UIC2] (ab272340) Separation of HepG2 (Human liver hepatocellular carcinoma cell line) cells (red-filled) from human peripheral whole blood cells (black-dashed) in … kit baustoffeWeb29 Jul 2003 · It was thus interesting to add another antibodies such as UIC2, the specificity of which was previously thought to be very high. UIC2 is specific for the extracellular moiety of the human mdr1 Pgp (Mechetner and Roninson 1992). UIC2 does not react with the products of mdr2 or mdr3 human genes, which are not implicated in the MDR process. … kit bauletto tracer 7 2022WebThe antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze. Application FC - Quality tested. Recommended … kit becomes a zombieWebBuy mouse monoclonal (UIC2) antibody to CD243 (A121698). Validated Applications: Flow Cytometry. Reactivity: Human. ️ Low Prices ️ 100% Guarantee m6 fitness camarilloWeb24 Aug 2024 · UIC2 antibody was prepared from hybridoma cells as described in the text. FITC-labeled anti-mouse secondary antibody IgG2a was obtained from BD Biosciences … m6 film romance