WebbThe epidermis-specific TM knockout mice were generated to investigate the function of TM in these biological processes. Primary cultured keratinocytes obtained from TM (lox/lox); K5-Cre mice, in which TM expression was abrogated, underwent abnormal differentiation in response to calcium induction. WebbGender- and age-matched K5 Cre Act1 f/− and K5 Cre Act1 f/+ mice (littermate controls) were subjected to the DMBA/TPA regimen. Skin tumor formation occurred in the control mice (K5 Cre Act1 f/+) as early as 5 wk after TPA application, whereas K5 Cre Act1 f/− mice were strongly resistant to tumor formation ( Fig. 1, D and E ).
Dysregulation of Suppressor of Cytokine Signaling 3 in …
Webb13 sep. 2024 · Status: Public on Sep 12, 2024: Title: Loss of epigenetic regulation disrupts lineage commitment and promotes breast cancer: Organism: Mus musculus: Experiment type WebbC5. C5 kan syfta på. C6 – en kuvertstorlek, se C-format. C5 (tunnelbanevagn) – en typ av tunnelbanevagn i Stockholms tunnelbana. Sinclair C5 – en eldriven trehjuling. Citroën … gift in hindi meaning
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Webb7 dec. 2024 · To address if the prosurvival proteins encoded by these genes are important for TEC homeostasis and the maintenance of thymic function, Jain et al specifically deleted these genes only in TECs by using Foxn1 Cre or K5 Cre. TEC-specific deletion of Bcl2 or Bcl2l1 did not reveal abnormalities in the thymus. WebbRNA-Seq analysis indicated that Sprr2d, a member of the small proline-rich protein 2 family, in the skin tissues of the Ncstn flox/flox;K5-Cre mice was also upregulated on … WebbTo delineate cell type-specific contributions of IL-17/CIKS-mediated signaling in IMQ-induced psoriasis, we generated mice in which CIKS was conditionally deleted in keratinocytes via a K5-driven Cre recombinase ( Traf3ip2-/flx; K5-cre ), hereafter referred to as “CIKS K5-KO” mice. gifting your house to your son