Eif4a1 eif4a2

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August undefined, 2024

WebDescription: Homo sapiens programmed cell death 4 (PDCD4), transcript variant 1, mRNA. (from RefSeq NM_014456) RefSeq Summary (NM_014456): This gene is a tumor suppressor and encodes a protein that binds to the eukaryotic translation initiation factor 4A1 and inhibits its function by preventing RNA binding. Alternative splicing results in … WebDec 2, 2024 · eIF4A2 forms an endogenous complex with CNOT1. eIF4A1 and eIF4A2 have been reported to have non-redundant divergent roles in translation regulation [11, …

Translation initiation factor eIF4F modifies the dexamethasone …

WebJun 15, 2016 · Whereas both eIF4A1 and eIF4A2 interact with eIF4G, eIF4A2, but not eIF4A1, binds cNOT7 (Meijer et al., 2013). cNOT7 is a member of the CCR4–NOT complex, that is required for deadenylation of mRNA, and for microRNA (miRNA)-mediated gene regulation, indicating a specific role for eIF4A2 in this process. WebSep 30, 2015 · Nielsen and Trachsel (1988) found that eif4a1 was expressed at similar levels in all mouse tissues examined, while eif4a2 had a much more varied pattern of expression. Kim et al. (1993) cloned the human EIF4A1 cDNA. The EIF4A1 cDNA encodes a predicted 406-amino acid polypeptide with 92.7% amino acid similarity to the mouse … hyunjin stray kids new haircut

Phospho-eIF4A1 (Tyr48) Polyclonal Antibody (PA5-105329)

WebJun 14, 2016 · Whether eIF4A2 plays a significant role in response to rocaglate-mediated inhibition and could be responsible for the partial sensitivity of eIF4A1 em1JP to high rocaglate concentration (Figure S2 B) remains to be elucidated. Nevertheless, these results consolidate the position of eIF4A1 as an anti-cancer target. WebTarget Information. eIF4A2 is a 407 amino acid ATP-dependent RNA helicase belonging to the DEAD box helicase family. It contains one helicase ATP-binding domain and a helicase C-terminal domain. eIF4A2, a subunit of the eIF4F complex, acts as a protein-synthesis initiation factor and thus plays an important role in the binding of mRNA to the ... http://www.licpathway.net/sedb/download/new/SE_bed/mm10/SE_12_0095_SE_mm10.bed molly rainford and hrvy

Discovery and Characterization of a Eukaryotic Initiation

EIF4A1 Gene - GeneCards IF4A1 Protein IF4A1 Antibody

WebFeb 18, 2024 · accounting involves using auditing quantitative methods and related investigative skills to reconstruct financial records and determine if fraud or WebMar 21, 2024 · EIF4A1 (Eukaryotic Translation Initiation Factor 4A1) is a Protein Coding gene. Diseases associated with EIF4A1 include Fragile X-Associated Tremor/Ataxia … molly rainford bgt 2012WebApr 5, 2024 · The eukaryotic initiation factor-4A (eIF4A) family consists of 3 closely related proteins EIF4A1, EIF4A2, and EIF4A3. In addition, these proteins are helicases that function to unwind double-stranded RNA. Furthermore, CMLD012073 is an amidino-rocaglates and is a potent eukaryotic initiation factor 4A (eIF4A) inhibitor. In particular, rocailles ... molly rainford brother billy

"WebMay 3, 2013 · Eukaryotic initiation factor 4A plays an important role in the binding of mRNA to the 43S preinitiation complex when protein synthesis begins. Two highly homologous … " - Eif4a1 eif4a2

Eif4a1 eif4a2

EUKARYOTIC TRANSLATION INITIATION FACTOR 4A, ISOFORM 2; …

WebNov 21, 2024 · eIF4A1 and eIF4A2 are similarly affected by all active rocaglates • Amidino-rocaglates were identified as a novel potent class of translation inhibitors • A novel lead compound, CMLD012612, was identified and characterized Introduction WebJun 14, 2024 · A Heatmap of gene expressions of eIF4A1, eIF4A2, eIF4G1, eIF4G2, eIF4G3, and eIF4E in human primary cancer specimens including leukemia in a publicly …

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Webse_chr se_start se_end se_id cell_id se_rank se_ele_num se_cas_value se_con_value se_gene_overlap se_gene_proximal se_gene_closest se_gene_prestige se_gene_closest_active se_snp_n WebNov 28, 2024 · The deduced eIF4A1/eIF4A2 homologs in Physcomitrella were observed to be ~ 98% identical while though Pp3s93_30V3.1 and Pp3c6_1080V3.1 shared almost 100% identity, transcripts for both the genes could be detected as described below. With Arabidopsis and rice eIF4A1/eIF4A2, each of the Physcomitrella eIF4A1/eIF4A2 …

WebTarget Information. eIF4A2 is a 407 amino acid ATP-dependent RNA helicase belonging to the DEAD box helicase family. It contains one helicase ATP-binding domain and a … WebJan 23, 2015 · To examine the mRNAs that were particularly dependent on eIF4A1 expression, Modelska et al. decreased the expression of this protein using siRNA in the ER-positive breast carcinoma cell line MCF7 ...

WebPredominantly nuclear under normal growth conditions, and when phosphorylated at Ser-457 (PubMed:16357133). Up-regulated in proliferative cells. Highly expressed in epithelial cells of the mammary gland. Reduced expression in lung cancer and colon carcinoma. Interacts (via MI domains) with EIF4A2 (By similarity). Interacts (via MI domains) with ... WebSep 10, 2024 · A screen of >200 rocaglates identified a novel, potent chemical series, amidino-rocaglates, that target eIF4A1 and eIF4A2 to potently inhibit translation and tumor cell viability, and are effective in …

WebPolyclonal Antibody for studying eIF4A2/eIF4A1/eIF4A3. Cited in 12 publications. Validated for Western Blotting. Highly specific and rigorously validated in-house, eIF4A (F52) Antibody (CST #2425) is ready to ship.

WebMay 24, 2024 · Hello, I Really need some help. Posted about my SAB listing a few weeks ago about not showing up in search only when you entered the exact name. I pretty … hyunjin\u0027s drawing for felixWebMar 25, 2024 · SaraOmranian Create PIPS_Final.txt. Latest commit c71e5f8 on Mar 24, 2024 History. 1 contributor. 5385 lines (5385 sloc) 59.7 KB. Raw Blame. RFC4 RFC3. PSMA2 PSMA5. SNRPD2 LSM5. LSM7 LSM2. molly rainford argentine tangoWebIn American English, these words would generally be pronounced with a shorter /a/ sound: ‘already’, ‘law’, ‘daughter’, ‘thought’. Also, like the other long vowel sounds you’ve seen, … hyunjin\\u0027s artworkWebSep 19, 2024 · Eukaryotic translation initiation factor (eIF) 4A — a DEAD-box RNA-binding protein — plays an essential role in translation initiation. Two mammalian eIF4A … hyunjin touch itWebApr 1, 2024 · Although both EIF4A1 and EIF4A2 display high protein homology and assemble into the EIF4F complex required for microRNA-mediated gene regulation, evidence suggests that EIF4A2, but not EIF4A1, plays a key role in this process of formation of the EIF4F complex ( Meijer, 2013 ). molly rainford motherWebEukaryotic translation initiation factor 4A2 (eIF4A2) is necessary for efficient HIV-1 replication in human lymphoid cell line. eIF4A2 depletion reduces the efficiency of viral … molly rainford tv showWebDec 14, 2024 · There are 3 identified isoforms eIF4A in humans. eIF4A1 is the major type that participates in the assembly of eIF4F in cancer cells. eIF4A2, which is mainly expressed in cells with low levels of proliferation, is correlated with a … molly rainford date of birth